Article
A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1.
Communications biology - 4 Apr 2022
Yang Yifeng, Lu Wenwen, Ning Mei, Zhou Xianhao, Wan Xinyao, Mi Qianglong, Yang Xiaoyan, Zhang Di, Zhang Yuanyuan, Jiang Biao, He Lin, Liu Jia, Zou Yan
Abstract excerpt
The aberrant expression or genomic mutations of microRNA are associated with several human diseases. This study analyzes the relationship between genetic variations of miRNA and schizophrenia or bipolar disorder. We performed case-control studies for ten SNPs in a total sample of 1584 subjects. All these ten SNPs were on or near mature microRNAs. We identified the association between bipolar disorder and the T/C...
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