Article
Genetic variations in miR-27a gene decrease mature miR-27a level and reduce gastric cancer susceptibility.
Oncogene - 9 Jan 2014
Yang Q, Jie Z, Ye S, Li Z, Han Z, Wu J, Yang C, Jiang Y
Abstract excerpt
MicroRNAs (miRNAs) are noncoding RNAs that function as post-transcriptional regulators of tumor oncogenes and suppressors. Single-nucleotide polymorphisms (SNPs) in miRNA genes are a novel class of genetic variations in the human genome that are currently being identified and investigated in human cancers. In this study, we aimed to investigate whether SNPs in the miR-27a gene affect miR-27a expression and alter...
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