Article
Genotype GG of rs895819 Functional Polymorphism Within miR-27a Might Increase Genetic Susceptibility to Colorectal Cancer in Han Chinese Population.
Journal of clinical laboratory analysis - 1 Jul 2016
Jiang Yu, Lin Dong-Hong, Xu Jian-Ping, Chen Wen-Xu, Zheng Shu-Jian, Song Lin
Abstract excerpt
BACKGROUND: MicroRNA-27a (miR-27a) is supposed to be an oncogene in various types of cancers, and genetic variation of miR-27a might result in aberrant expression and abnormal second structure of mature-miR-27a, contributing to elevated genetic risk and poor prognosis for colorectal cancer (CRC). METHODS: In order to explore the possible association between rs895819 within miR-27a and CRC in Han Chinese...
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