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Article

Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression.

Nature communications - 26 Feb 2024

Tian Ruoyu, Ge Tian, Kweon Hyeokmoon, Rocha Daniel B, Lam Max, Liu Jimmy Z, Singh Kritika, Levey Daniel F, Gelernter Joel, Stein Murray B, Tsai Ellen A, Huang Hailiang, Chabris Christopher F, Lencz Todd, Runz Heiko, Chen Chia-Yen

Abstract excerpt

Nearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS). However, the impact of rare coding variants on depression remains poorly understood. Here, we present whole-exome sequencing analyses of depression with seven different definitions based on survey, questionnaire, and electronic health records in 320,356 UK Biobank participants. We showed that the...

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PMID: 38409228
DOI: 10.1038/s41467-024-45774-2
PMCID: PMC10897433

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