Article
Potential genetic biomarkers are found to be associated with both cognitive function and blood pressure: A bivariate genome-wide association analysis.
Mechanisms of ageing and development - 1 Jun 2022
Zhang Liming, Wang Weijing, Xu Chunsheng, Duan Haiping, Tian Xiaocao, Zhang Dongfeng
Abstract excerpt
A bivariate genome-wide association study was conducted in 137 pairs of twins to explore the shared genetic loci between cognition and blood pressure (BP). Before SNPs imputation, rs72815554 is significantly (P < 5 × 10-8) associated with the cognition-pulse pressure (PP) phenotype, while after imputation, 4 and 9 SNPs are significantly associated with the cognition-SBP phenotype, and cognition-PP phenotype,...
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