Article
POLE mutation combined with microcystic, elongated and fragmented (MELF) pattern invasion in endometrial carcinomas might be associated with poor survival in Chinese women.
Gynecologic oncology - 1 Oct 2020
He Dan, Wang Hui, Dong Ying, Zhang Yan, Zhao Jian, Lv Conghui, Zheng Xianjing, Li Dong, Li Ting
Abstract excerpt
OBJECTIVE: POLE mutation is a prognostic marker associated with excellent outcome in endometrial carcinoma (EC). However, these EC tumors frequently have aggressive histology. The aim of this study was to determine how to integrate the implications of POLE mutations into existing risk assessment strategies and further stratify patients. METHODS: We detected POLE mutations in a cohort of 426 ECs from Chinese women...
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