Article
Clinically relevant molecular subtypes and genomic alteration-independent differentiation in gynecologic carcinosarcoma.
Nature communications - 31 Oct 2019
Gotoh Osamu, Sugiyama Yuko, Takazawa Yutaka, Kato Kazuyoshi, Tanaka Norio, Omatsu Kohei, Takeshima Nobuhiro, Nomura Hidetaka, Hasegawa Kosei, Fujiwara Keiichi, Taki Mana, Matsumura Noriomi, Noda Tetsuo, Mori Seiichi
Abstract excerpt
Carcinosarcoma (CS) of the uterus or ovary is a rare, aggressive and biphasic neoplasm composed of carcinoma and sarcoma elements. Previous genomic studies have identified the driver genes and genomic properties associated with CS. However, there is still no molecular subtyping scheme with clinical relevance for this disease. Here, we sequence 109 CS samples, focusing on 596 genes. We identify four molecular...
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