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Article

Targeting Wnt Signaling for the Treatment of Gastric Cancer.

International journal of molecular sciences - 30 May 2020

Koushyar Sarah, Powell Arfon G, Vincan Elizabeth, Phesse Toby J

Abstract excerpt

The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeostasis. Wnt signaling controls several fundamental cell functions, including proliferation, differentiation, migration, and stemness. It therefore plays an important role in the epithelial homeostasis and regeneration of the gastrointestinal tract. Often, both hypo- or hyper-activation of...

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beta Catenin
Cell Movement
Epithelial-Mesenchymal Transition
Frizzled Receptors
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Stomach Neoplasms

Wnt Signaling Pathway

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Identifiers

PMID: 32486243
DOI: 10.3390/ijms21113927
PMCID: PMC7311964

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