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Article

Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?

6 Mar 2014

Abstract excerpt

Acquired resistance toward apoptosis represents one of the hallmarks of human cancer and a major cause of the inefficacy of most anticancer treatment regimens. Based on its ability to inhibit apoptosis, the B-cell lymphoma/leukemia 2 (Bcl-2) protein family has garnered the most attention as a promising therapeutic target in cancer. Accordingly, efforts have lately been focused on the development of drugs...

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PMID: 24603326
DOI: 10.1038/cddis.2014.61

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