Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels.

doi:10.3390/ijms251810154

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Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels.

International journal of molecular sciences - 21 Sept 2024

Nolasco-Rosales Germán Alberto, Martínez-Magaña José Jaime, Juárez-Rojop Isela Esther, Rodríguez-Sánchez Ester, Ruiz-Ramos David, Villatoro-Velázquez Jorge Ameth, Bustos-Gamiño Marycarmen, Medina-Mora Maria Elena, Tovilla-Zárate Carlos Alfonso, Cruz-Castillo Juan Daniel, Nicolini Humberto, Genis-Mendoza Alma Delia

Abstract excerpt

Latent autoimmune diabetes in adults (LADA) is characterized by the presence of glutamate decarboxylase autoantibodies (GADA). LADA has intermediate features between type 1 diabetes and type 2 diabetes. In addition, genetic risk factors for both types of diabetes are present in LADA. Nonetheless, evidence about the genetics of LADA in non-European populations is scarce. This study aims to perform a genome-wide...

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PMID: 39337639
DOI: 10.3390/ijms251810154
PMCID: PMC11432505

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