Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.

doi:10.1002/ana.25216

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Article

Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.

Annals of neurology - 1 Apr 2018

Mueller Stefanie H, Färber Anna, Prüss Harald, Melzer Nico, Golombeck Kristin S, Kümpfel Tania, Thaler Franziska, Elisak Martin, Lewerenz Jan, Kaufmann Max, Sühs Kurt-Wolfram, Ringelstein Marius, Kellinghaus Christoph, Bien Christian G, Kraft Andrea, Zettl Uwe K, Ehrlich Sven, Handreka Robert, Rostásy Kevin, Then Bergh Florian, Faiss Jürgen H, Lieb Wolfgang, Franke Andre, Kuhlenbäumer Gregor, Wandinger Klaus-Peter, Leypoldt Frank

Abstract excerpt

We performed a genome-wide association study in 1,194 controls and 150 patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR, n = 96) or anti-leucine-rich glioma-inactivated1 (anti-LGI1, n = 54) autoimmune encephalitis. Anti-LGI1 encephalitis was highly associated with 27 single-nucleotide polymorphisms (SNPs) in the HLA-II region (leading SNP rs2858870 p = 1.22 × 10-17 , OR = 13.66 [7.50-24.87])....

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Identifiers

PMID: 29572931
DOI: 10.1002/ana.25216

Genes

LGI1
DCLK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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