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Sperm chromatin: Evaluation, epigenetic signatures and relevance for embryo development and assisted reproductive technology outcomes

15 Jun 2024

Abstract excerpt

Sperm chromatin is distinct from somatic cell chromatin, as a result of extensive remodeling during the final stages of spermatogenesis. In this process, the majority of histones is replaced with protamines. The chromatin is consequently highly condensed and inert, which facilitates protection of the DNA. The sperm epigenomic landscape is shaped by histone retention, histone and protamine modification, DNA...

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PMID: 38905808
DOI: 10.1016/j.ejcb.2024.151429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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