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Progress on the Physiological Function of Mitochondrial DNA and Its Specific Detection and Therapy.

Chembiochem : a European journal of chemical biology - 16 Feb 2022

Zhang Congcong, Xue Yufei, Wang Lan, Wu Qiong, Fang Bin, Sheng Yu, Bai Hua, Peng Bo, Yang Naidi, Li Lin

Abstract excerpt

Mitochondrial DNA (mtDNA) is the genetic information of mitochondrion, and its structure is circular double-stranded. Despite the diminutive size of the mitochondrial genome, mtDNA mutations are an important cause of mitochondrial diseases which are characterized by defects in oxidative phosphorylation (OXPHOS). Mitochondrial diseases are involved in multiple systems, particularly in the organs that are highly...

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PMID: 34661371
DOI: 10.1002/cbic.202100474

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