Article
Regulation of the Late Onset alzheimer's Disease Associated HLA-DQA1/DRB1 Expression.
American journal of Alzheimer's disease and other dementias - 1 Jan 2000
Zhang Xiaoyu, Zou Meijaun, Wu Yuwei, Jiang Danli, Wu Ting, Zhao Yihan, Wu Di, Cui Jing, Li Gang
Abstract excerpt
(Genome-wide Association Studies) GWAS have identified ∼42 late-onset Alzheimer's disease (LOAD)-associated loci, each of which contains multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) and most of these SNPs are in the non-coding region of human genome. However, how these SNPs regulate risk gene expression remains unknown. In this work, by using a set of novel techniques, we...
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