Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms.

doi:10.1016/j.pan.2022.03.007

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Article

Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 May 2022

Schmidt Andreas W, Kühnapfel Andreas, Kirsten Holger, Grallert Harald, Hellerbrand Claus, Kiefer Falk, Mann Karl, Mueller Sebastian, Nöthen Markus M, Peters Annette, Ridinger Monika, Frank Josef, Rietschel Marcella, Soranzo Nicole, Soyka Michael, Wodarz Norbert, Malerba Giovanni, Gambaro Giovanni, Gieger Christian, Scholz Markus, Krug Sebastian, Michl Patrick, Ewers Maren, Witt Heiko, Laumen Helmut, Rosendahl Jonas

Abstract excerpt

BACKGROUND: Previous genome-wide association studies (GWAS) identified genome-wide significant risk loci in chronic pancreatitis and investigated underlying disease causing mechanisms by simple overlaps with expression quantitative trait loci (eQTLs), a procedure which may often result in false positive conclusions. METHODS: We conducted a GWAS in 584 non-alcoholic chronic pancreatitis (NACP) patients and 6040...

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PMID: 35331647
DOI: 10.1016/j.pan.2022.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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