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TERT promoter methylation is associated with high expression of TERT and poor prognosis in papillary thyroid cancer

19 Jan 2024

Abstract excerpt

The telomerase reverse transcriptase (TERT) is overexpressed and associated with poor prognosis in papillary thyroid cancer (PTC), the most common subtype of thyroid cancer. The overexpression of TERT in PTC was partially attributed to transcriptional activation by two hotspot mutations in the core promoter region of this gene. As one of the major epigenetic mechanisms of gene expression regulation, DNA...

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PMID: 38313800
DOI: 10.3389/fonc.2024.1325345

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