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Article

DDX21 Links BRAFV600E and TERT to Promote Thyroid Cancer Progression.

Thyroid : official journal of the American Thyroid Association - 1 Mar 2026

Chen Mengke, Jiang Ke, Zhang Qi, Xiao Xi, Zhu Lefan, Sang Ye, Hu Guanghui, Yu Shuang, Hong Shubin, Lv Weiming, Xiao Haipeng, Liu Rengyun

Abstract excerpt

BACKGROUND: The coexistence of BRAFV600E and telomerase reverse transcriptase (TERT) promoter alterations has been reported to cooperatively upregulate TERT expression and is well recognized as a biomarker for aggressive thyroid cancer. However, the mechanism underlying their synergistic effect remains elusive. METHODS: TERT-interacting proteins were identified via immunoprecipitation (IP) and mass spectrometry...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41817108
DOI: 10.1177/10507256261417697

Genes

DDX21
TERT
BRAF
GABPA
GABPB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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DDX21 Links BRAFV600E and TERT to Promote Thyroid Cancer Progression.PMID 41817108Read ↗

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TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesisSemantic proximity Read ↗

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Promoter mutation-independent TERT expression is related to the immune-enriched milieu in papillary thyroid cancer.Semantic proximity Read ↗

Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas.Semantic proximity Read ↗

Multiple ETS Factors Participate in the Transcriptional Control of TERT Mutant Promoter in Thyroid CancersSemantic proximity Read ↗

Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients.Semantic proximity Read ↗

DEPDC1 Promotes Thyroid Cancer Migration, Invasion, and Proliferation, and Correlates with Poor PrognosisSemantic proximity Read ↗

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