Reentry in cardiac ventricular epicardial tissue due to SCN5A L812Q gene mutation: a computational study.

Abstract excerpt

Cardiovascular diseases are the major cause of sudden death. Brugada syndrome is an inherited rare disease, that leads to death due to ventricular fibrillation (VF). Brugada Syndrome is related to mutations in the genes that encode SCN5A, a subunit of sodium ion channel (NaV). This computational study investigates the mechanism of loss of function gene mutation (SCN5A L812Q) in sodium ion channel that leads to...

Topics

• Brugada Syndrome
• Humans
• Mutation
• NAV1.5 Voltage-Gated Sodium Channel
• Ventricular Fibrillation