Computational prediction of the effect of D172N KCNJ2 mutation on ventricular pumping during sinus rhythm and reentry.

doi:10.1007/s11517-020-02124-w

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Article

Computational prediction of the effect of D172N KCNJ2 mutation on ventricular pumping during sinus rhythm and reentry.

Medical & biological engineering & computing - 1 May 2020

Heikhmakhtiar Aulia Khamas, Lee Chung Hao, Song Kwang Soup, Lim Ki Moo

Abstract excerpt

The understanding of cardiac arrhythmia under genetic mutations has grown in interest among researchers. Previous studies focused on the effect of the D172N mutation on electrophysiological behavior. In this study, we analyzed not only the electrophysiological activity but also the mechanical responses during normal sinus rhythm and reentry conditions by using computational modeling. We simulated four different...

Topics

Arrhythmias, Cardiac
Heart Ventricles
Humans
Models, Cardiovascular
Mutation
Potassium Channels, Inwardly Rectifying
Ventricular Function

Source

Open in PubMed

Identifiers

PMID: 32095980
DOI: 10.1007/s11517-020-02124-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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