Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational Study on Effect of KCNQ1 P535T Mutation in a Cardiac Ventricular Tissue.

The Journal of membrane biology - 1 Jun 2023

Satish Helan, Machireddy Ramasubba Reddy

Abstract excerpt

Heart diseases such as arrhythmia are the main causes of sudden death. Arrhythmias are typically caused by mutations in specific genes, damage in the cardiac tissue, or due to some chemical exposure. Arrhythmias caused due to mutation is called inherited arrhythmia. Induced arrhythmias are caused due to tissue damage or chemical exposure. Mutations in genes that encode ion channels of the cardiac cells usually...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to KCNQ Potassium Channels
Share to KCNQ1 Potassium Channel
Share to Long QT Syndrome

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Potassium Channels

Share to Romano-Ward Syndrome

Source

Identifiers

PMID: 37166559
DOI: 10.1007/s00232-023-00287-9

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational Study on Effect of KCNQ1 P535T Mutation in a Cardiac Ventricular Tissue.PMID 37166559Read ↗

Computational prediction of the effect of D172N KCNJ2 mutation on ventricular pumping during sinus rhythm and reentry.Semantic proximity Read ↗

Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram.Semantic proximity Read ↗

Reentry in cardiac ventricular epicardial tissue due to SCN5A L812Q gene mutation: a computational study.Semantic proximity Read ↗

A Simulation Study on Electrical Activity of Ventricular Endocardial Tissue due to SCN5A L812Q Mutation.Semantic proximity Read ↗

Modeling of IK1 mutations in human left ventricular myocytes and tissue.Semantic proximity Read ↗

Computational analysis of the effect of KCNH2 L532P mutation on ventricular electromechanical behaviors.Semantic proximity Read ↗

Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber.Semantic proximity Read ↗

Proarrhythmogenic Effect of the L532P and N588K KCNH2 Mutations in the Human Heart Using a 3D Electrophysiological Model.Semantic proximity Read ↗

Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol.Semantic proximity Read ↗

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk AssessmentSemantic proximity Read ↗

HPC framework for in-silico trials on 3D virtual human cardiac population to assess drug-induced arrhythmic riskSemantic proximity Read ↗

Ion Channel Dysfunction Associated With Arrhythmia, Ventricular Noncompaction, and Mitral Valve ProlapseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.