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Article

A novel fusion between CDC42BPB and ALK in a patient with quadruple wild-type gastrointestinal stromal tumor.

Molecular genetics & genomic medicine - 1 May 2022

Huang Wen, Yuan Wei, Ren Lei, Xu Chen, Luo Rongkui, Zhou Yuhong, Lu Weiqi, Hao Qing, Xu Mian, Hou Yingyong

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common type of mesenchymal tumor in gastrointestinal tract, with striking features of morphology and immunohistochemistry. But GISTs in pregnancy could seldom be found. Pathogenic activating mutations of the proto-oncogene KIT and PDGFRA are detected in majority GISTs, and adjuvant imatinib therapy targeting KIT and PDGFRA mutations is recommended...

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Identifiers

PMID: 35319816
DOI: 10.1002/mgg3.1881
PMCID: PMC9034673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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