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Article

Genetically predicted frailty index and risk of stroke and Alzheimer's disease.

European journal of neurology - 1 Jul 2022

Liu Weishi, Zhang Luyang, Fang Hui, Gao Yuan, Liu Kai, Li Shen, Liu Hongbing, Wang Xin, Liu Chen, Song Bo, Xia Zongping, Xu Yuming

Abstract excerpt

BACKGROUND AND PURPOSE: Previous studies have reported the association between frailty and stroke or Alzheimer's disease (AD). However, the causality remains unclear. The aim of the present study was to evaluate whether genetically predicted frailty is associated with the risk of stroke or AD by a Mendelian randomization (MR) study. METHODS: Genetic variants associated with the frailty index (FI) were obtained...

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PMID: 35318774
DOI: 10.1111/ene.15332

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