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Article

Monitoring of Circulating CAR T Cells: Validation of a Flow Cytometric Assay, Cellular Kinetics, and Phenotype Analysis Following Tisagenlecleucel.

Frontiers in immunology - 1 Jan 2022

Peinelt Andreas, Bremm Melanie, Kreyenberg Hermann, Cappel Claudia, Banisharif-Dehkordi Julia, Erben Stephanie, Rettinger Eva, Jarisch Andrea, Meisel Roland, Schlegel Paul-Gerhardt, Beck Olaf, Bug Gesine, Klusmann Jan-Henning, Klingebiel Thomas, Huenecke Sabine, Bader Peter

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy is a potent new treatment option for relapsed or refractory hematologic malignancies. As the monitoring of CAR T cell kinetics can provide insights into the activity of the therapy, appropriate CAR T cell detection methods are essential. Here, we report on the comprehensive validation of a flow cytometric assay for peripheral blood CD19 CAR T cell detection. Further,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 35309367
DOI: 10.3389/fimmu.2022.830773
PMCID: PMC8926389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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