Article

Decade-long remissions of leukemia sustained by the persistence of activated CD4 <sup>+</sup> CAR T-cells

2021-05-07

Abstract excerpt

The adoptive transfer of T lymphocytes reprogrammed to target tumor cells has demonstrated significant potential in various malignancies. However, little is known about the long-term potential and the clonal stability of the infused cells. Here, we studied the longest persisting CD19-redirected chimeric antigen receptor (CAR) T cells to date in two chronic lymphocytic leukemia (CLL) patients who achieved a complet...

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Literature Corpus work: 322c773f-bc00-52a8-8cae-28718d6665a8
DOI: 10.1101/2021.05.07.443194

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