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Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain–gut axis

21 Dec 2015

Abstract excerpt

BACKGROUND: Chronic psychological stress is associated with enhanced abdominal pain and altered intestinal barrier function that may result from a perturbation in the hypothalamic-pituitary-adrenal (HPA) axis. The glucocorticoid receptor (GR) exploits diverse mechanisms to activate or suppress congeneric gene expression, with regulatory variation associated with stress-related disorders in psychiatry and...

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PMID: 26690871
DOI: 10.1111/nmo.12706

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