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Experimental evolution links post-transcriptional regulation to Leishmania fitness gain

16 Mar 2022

Abstract excerpt

The protozoan parasite Leishmania donovani causes fatal human visceral leishmaniasis in absence of treatment. Genome instability has been recognized as a driver in Leishmania fitness gain in response to environmental change or chemotherapy. How genome instability generates beneficial phenotypes despite potential deleterious gene dosage effects is unknown. Here we address this important open question applying...

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PMID: 35294501
DOI: 10.1371/journal.ppat.1010375

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