Article

Genome instability drives epistatic adaptation in the human pathogen <i>Leishmania</i>

2021-06-15

Abstract excerpt

How genome instability is harnessed for fitness gain despite its potential deleterious effects is largely elusive. An ideal system to address this important open question is provided by the protozoan pathogen Leishmania , which exploits frequent variations in chromosome and gene copy number to regulate expression levels. Using ecological genomics and experimental evolution approaches we provide first evidence tha...

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Literature Corpus work: 8d82d9b6-3229-59a7-bb1f-9b4ee81b64bd
DOI: 10.1101/2021.06.15.448517

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