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Mutation of MtrA at the Predicted Phosphorylation Site Abrogates Its Role as a Global Regulator in Streptomyces venezuelae.

Microbiology spectrum - 27 Apr 2022

Lu Ting, Zhu Yanping, Ni Xue, Zhang Xia, Liu Yang, Cui Xiqing, Pang Xiuhua

Abstract excerpt

The global regulator MtrA controls development and primary and secondary metabolism in Streptomyces species. However, residues critical for its function have not yet been characterized. In this study, we identified residue D53 as the potential phosphorylation site of MtrA from Streptomyces venezuelae, a model Streptomyces strain. MtrA variants with amino acid substitutions at the D53 site were generated, and the...

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Identifiers

PMID: 35293797
DOI: 10.1128/spectrum.02131-21
PMCID: PMC9045223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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