Phosphoproteome Analysis of <i>Streptomyces</i> Development Reveals Extensive Protein Phosphorylation Accompanying Bacterial Differentiation

Abstract excerpt

Streptomycetes are bacterial species that undergo a complex developmental cycle that includes programmed cell death (PCD) events and sporulation. They are widely used in biotechnology because they produce most clinically relevant secondary metabolites. Although Streptomyces coelicolor is one of the bacteria encoding the largest number of eukaryotic type kinases, the biological role of protein phosphorylation in...