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Article

MtrAB activates ectoine production and triggers sporulation in response to osmotic stress in Streptomyces venezuelae.

Microbiology (Reading, England) - 1 May 2026

Beaton Ainsley D M, Devine Rebecca, Holmes Neil A, Som Nicolle F, Balis Lucas, Noble Katie, Stringer Rhea, Rejzek Martin, Saalbach Gerhard, Wilkinson Barrie, Hutchings Matthew I

Abstract excerpt

The MtrAB two-component system is a master regulator of antibiotic biosynthesis in Streptomyces species. MtrA is also required for sporulation under certain growth conditions, which means that on some growth media, ∆mtrA mutant colonies do not produce aerial hyphae or spores. These mutants are referred to as (conditionally) bald because they lack the hairy appearance of wild-type colonies. Here, we report that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42160210
DOI: 10.1099/mic.0.001706
PMCID: PMC13189361

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