Article
Whole-genome sequencing identifies rare missense variants of WNT16 and ERVW-1 causing the systemic lupus erythematosus.
Genomics - 1 May 2022
Chen Jianhai, Zhang Ping, Chen Haidi, Wang Xin, He Xuefei, Zhong Jie, Zheng HuaPing, Li Xiaoyu, Jakovlić Ivan, Zhang Yong, Chen Younan, Shen Bairong, Deng Cheng, Wu Yongkang
Abstract excerpt
Systemic lupus erythematosus (SLE, OMIM 152700) is a rare autoimmune disease with high heritability that affects ~0.1% of the population. Previous studies have revealed several common variants with small effects in European and East Asian SLE patients. However, there is still no rare variant study on Chinese SLE patients using the whole-genome sequencing technology (WGS). Here, we designed a family based WGS...
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