A multi-omics approach to identify molecular alterations in a mouse model of heart failure

Abstract excerpt

The morbidity and mortality of heart failure (HF) have been increasing rapidly in recent years. However, the molecular events that link to the phenotype of HF remain unclear. This study aimed to investigate the molecular alterations in the pathogenesis of HF induced by pressure overload. Methods: Transverse aortic constriction was conducted to generate the HF mouse model. A multi-omics study was performed,...

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