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Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

2024-06-27

Abstract excerpt

<h4>Background</h4> Hypertrophic cardiomyopathy (HCM) is characterized by massive myocardial hypertrophy, which is the most frequent cause of sudden death and can lead to heart failure (HF) or stroke. The objective of this study was to explore the communication network among various cells in the heart of pathological HCM derived from transverse aortic constriction (TAC) mouse model, and investigate the potential...

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Literature Corpus work
800e1406-0e09-59cc-ad93-4144ac66a6a3
DOI
10.1101/2024.06.25.600722
Open publication

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Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophyDOI 10.1101/2024.06.25.600722
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