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Design of a targeted next-generation DNA sequencing panel for pediatric T-cell lymphoblastic lymphoma to unravel biology and optimize treatment.

Genes, chromosomes & cancer - 1 Aug 2022

Ruether Charlotte, Wuensch Christian, Randau Gerrit, Michgehl Ulf, Trautmann Marcel, Hartmann Wolfgang, Sandmann Sarah, Dugas Martin, Khanam Tasneem, Burkhardt Birgit

Abstract excerpt

Low incidence and molecular heterogeneity of pediatric T-cell lymphoblastic lymphoma (T-LBL) require an international, large-scale effort to identify novel clinical biomarkers. The ongoing international clinical trial LBL2018 (NCT04043494) represents an ideal opportunity to implement a common analytic approach. Targeted next-generation sequencing is well-suited for this purpose; however, selection of relevant...

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Identifiers

PMID: 35278000
DOI: 10.1002/gcc.23037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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