Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis.

Biology open - 24 Jun 2020

Sam Jessica, Mercer Emily J, Torregroza Ingrid, Banks Kelly M, Evans Todd

Abstract excerpt

The Gata4/5/6 sub-family of zinc finger transcription factors regulate many aspects of cardiogenesis. However, critical roles in extra-embryonic endoderm also challenge comprehensive analysis during early mouse cardiogenesis, while zebrafish models have previously relied on knockdown assays. We generated targeted deletions to disrupt each gata4/5/6 gene in zebrafish and analyzed cardiac phenotypes in single,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GATA4 Transcription Factor
Share to GATA6 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Gene Targeting

Share to Morphogenesis

Share to Organogenesis

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 32580940
DOI: 10.1242/bio.053611
PMCID: PMC7327998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis.PMID 32580940Read ↗

Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes.Semantic proximity Read ↗

Gata4 and Gata5 Cooperatively Regulate Cardiac Myocyte Proliferation in MiceSemantic proximity Read ↗

A threshold of GATA4 and GATA6 expression is required for cardiovascular development.Semantic proximity Read ↗

From embryogenesis to adulthood: Critical role for GATA factors in heart development and functionSemantic proximity Read ↗

GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fateSemantic proximity Read ↗

GATA5 interacts with GATA4 and GATA6 in outflow tract development.Semantic proximity Read ↗

Parsing the Roles of the Transcription Factors GATA-4 and GATA-6 in the Adult Cardiac Hypertrophic ResponseSemantic proximity Read ↗

GATA4 is a dosage-sensitive regulator of cardiac morphogenesisSemantic proximity Read ↗

GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesisSemantic proximity Read ↗

Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders.Semantic proximity Read ↗

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.Semantic proximity Read ↗

Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.