Article
A threshold of GATA4 and GATA6 expression is required for cardiovascular development.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jul 2006
Xin Mei, Davis Christopher A, Molkentin Jeffery D, Lien Ching-Ling, Duncan Stephen A, Richardson James A, Olson Eric N
Abstract excerpt
The zinc-finger transcription factors GATA4 and GATA6 play critical roles in embryonic development. Mouse embryos lacking GATA4 die at embryonic day (E) 8.5 because of failure of ventral foregut closure and cardiac bifida, whereas GATA6 is essential for development of the visceral endoderm. Although mice that are heterozygous for either a GATA4 or GATA6 null allele are normal, we show that compound heterozygosity...
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