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Article

A novel phenotype-based drug-induced liver injury causality assessment tool (DILI-CAT) allows for signal confirmation in early drug development.

Alimentary pharmacology & therapeutics - 1 Apr 2022

Hermann Richard P, Rockey Don C, Suzuki Ayako, Merz Michael, Tillmann Hans L

Abstract excerpt

BACKGROUND: Drug-induced liver injury (DILI) requires accurate case adjudication, with expert opinion being the current best practice. AIM: We utilised a novel DILI causality assessment tool (DILI-CAT), which uses drug-specific liver injury phenotypes, to examine potential DILI in early phase ximelagatran clinical development. METHODS: We conducted a retrospective analysis of liver injury events from four Stroke...

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Identifiers

PMID: 35266155
DOI: 10.1111/apt.16836
PMCID: PMC9164935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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