Article
Case definition and phenotype standardization in drug-induced liver injury.
Clinical pharmacology and therapeutics - 1 Jun 2011
Aithal G P, Watkins P B, Andrade R J, Larrey D, Molokhia M, Takikawa H, Hunt C M, Wilke R A, Avigan M, Kaplowitz N, Bjornsson E, Daly A K
Abstract excerpt
Drug-induced liver injury (DILI) is the most frequent reason cited for the withdrawal of approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. Investigators around the globe have begun to identify and study patients with DILI; several large registries and tissue banks are being established. In order to gain the maximum scientific benefit from these efforts, the definitions...
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