Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug-induced liver injury: past, present and future.

Pharmacogenomics - 1 May 2010

Daly Ann K

Abstract excerpt

Drug-induced liver injury (DILI) is a rare but potentially serious idiosyncratic reaction. By using candidate gene and genome-wide association studies, replicated associations for DILI susceptibility with HLA genes and genes relevant to drug metabolism have been detected, mainly since 2000. The HLA associations include a strong association between flucloxacillin-induced injury and the class I allele B*5701 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Chemical and Drug Induced Liver Injury
Share to Drug-Related Side Effects and Adverse Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forecasting

Share to Genome-Wide Association Study

Share to Glutathione Transferase

Share to Isoniazid

Share to Risk Factors

Source

Identifiers

PMID: 20415545
DOI: 10.2217/pgs.10.24

Genes

GSTM1
GSTT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug-induced liver injury: past, present and future.PMID 20415545Read ↗

Drug-Induced Liver Injury: Insights from Genetic StudiesSemantic proximity Read ↗

Pharmacogenomics in drug induced liver injury.Semantic proximity Read ↗

Idiosyncratic drug-induced liver injury: an update on the 2007 overview.Semantic proximity Read ↗

Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives.Semantic proximity Read ↗

Liver injury caused by drugs: an update.Semantic proximity Read ↗

Genetics of drug-induced liver injury: Current knowledge and future prospects.Semantic proximity Read ↗

Drug-induced liver injury.Semantic proximity Read ↗

Mechanisms of drug-induced liver injurySemantic proximity Read ↗

Genetic basis of drug-induced liver injury: present and future.Semantic proximity Read ↗

Genetic and Genomic Approaches to the Study of Drug-Induced Liver Injury.Semantic proximity Read ↗

Drug-induced liver injury: a safety review.Semantic proximity Read ↗

Predicting and preventing acute drug-induced liver injury: what's new in 2010?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.