Article
The influence of drug properties and host factors on delayed onset of symptoms in drug-induced liver injury.
Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2019
Gonzalez-Jimenez Andres, McEuen Kristin, Chen Minjun, Suzuki Ayako, Robles-Diaz Mercedes, Medina-Caliz Inmaculada, Bessone Fernando, Hernandez Nelia, Arrese Marco, Parana Raymundo, Lucena M Isabel, Stephens Camilla, Andrade Raúl J
Abstract excerpt
BACKGROUND & AIMS: Most patients with drug-induced liver injury (DILI) manifest clinical symptoms while on therapy, while some patients manifest days or weeks after drug cessation (delayed onset). This challenges DILI causality assessment and diagnosis. Factors contributing to the delayed onset phenotype are currently unknown. We explored factors contributing to delayed onset of DILI by analysing culprit drug...
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