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Article

FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2009

Ireland Helen A, Cooper Jackie A, Drenos Fotios, Acharya Jayshree, Mitchell Jacqueline P, Bauer Ken A, Morrissey James H, Esnouf M Peter, Humphries Stephen E

Abstract excerpt

OBJECTIVE: The purpose of this study was to determine the effect of a variant in EPCR (Ser219Gly), previously shown to affect EPCR shedding, on plasma FVII, FVIIa, and downstream markers of activated coagulation. METHODS AND RESULTS: Statistical analysis was undertaken in approximately 2000 healt...

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Identifiers

PMID: 19696402
DOI: 10.1161/ATVBAHA.109.191551
PMCID: PMC2775706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19696402-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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