Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver

Abstract excerpt

Significance Superbugs carrying a mobile colistin resistance gene ( mcr ) are jeopardizing the clinical efficacy of the last-line antibiotic colistin. The development of MCR inhibitors is urgently required to cope with antibiotic-resistance emergencies. Here, we show that silver (Ag + ) fully restores the susceptibility of mcr-1 –carrying superbugs against colistin both in vitro and in vivo. We found an...

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