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Article

In Vivo Targeting Replication Protein A for Cancer Therapy

18 Feb 2022

Abstract excerpt

Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for overall survival in smoking-related lung cancers. Similarly, relative expression of RPA is a predictive marker for response to chemotherapy. These observations are...

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Identifiers

PMID: 35251993
DOI: 10.3389/fonc.2022.826655

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