Article
DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer.
Molecular cancer therapeutics - 1 Dec 2003
Kashishian Adam, Douangpanya Heather, Clark Darcey, Schlachter Stephen T, Eary C Todd, Schiro Justin G, Huang Hongmei, Burgess Larry E, Kesicki Edward A, Halbrook James
Abstract excerpt
Cancer presents a difficult challenge for oncologists, as there are few therapies that specifically target disease cells. Existing treatment strategies rely heavily on physical and chemical agents that nonspecifically affect DNA metabolism. To improve the effectiveness of these treatments, we have identified a new class of protein kinase inhibitor that targets a major DNA repair pathway. A representative of this...
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