Article
Acceleration of the DNA methylation clock among lynch syndrome-associated mutation carriers.
BMC medical genomics - 4 Mar 2022
Cuadros Marta, Cano Carlos, Garcia-Rodriguez Sonia, Martín José Luis, Poyatos-Andujar Antonio, Ruiz-Cabello Francisco, Pedrinaci Susana, Durán Gema, Benavides Manuel, Bautista-Ojeda María Dolores, Pereda Teresa, Benitez-Cantos Maria Soledad, Medina Pedro, Blanco Armando, Gonzalez Antonio, Lizardi Paul
Abstract excerpt
BACKGROUND: DNA methylation (DNAm) age metrics have been widely accepted as an epigenetic biomarker for biological aging and disease. The purpose of this study is to assess whether or not individuals carrying Lynch Syndrome-associated mutations are affected in their rate of biological aging, as measured by the epigenetic clock. METHODS: Genome-wide bisulfite DNA sequencing data were generated using DNA from...
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