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Article

Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk.

Clinical epigenetics - 3 Jan 2020

Wang Ting, Maden Sean K, Luebeck Georg E, Li Christopher I, Newcomb Polly A, Ulrich Cornelia M, Joo Ji-Hoon E, Buchanan Daniel D, Milne Roger L, Southey Melissa C, Carter Kelly T, Willbanks Amber R, Luo Yanxin, Yu Ming, Grady William M

Abstract excerpt

BACKGROUND: Chronological age is a prominent risk factor for many types of cancers including colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even within the same age group, which may reflect heterogeneity in biological tissue aging between people. Epigenetic clocks based on DNA methylation are a useful measure of the biological aging process with the potential to serve as a...

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Identifiers

PMID: 31900199
DOI: 10.1186/s13148-019-0801-3
PMCID: PMC6942339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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