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Article

Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer.

Aging - 7 Jul 2025

Jung Su Yon, Pellegrini Matteo, Tan Xianglong, Yu Herbert

Abstract excerpt

BACKGROUND: Epigenetic clocks, estimated via DNA methylation (DNAm), reflect individuals' biological aging in multiple tissues and are associated with age-related diseases, but their functional role in colorectal cancer (CRC), an age-associated disease, remains unconclusive. DNAm in tumor tissues exclusively exhibits cancerization with expansion of a stem cell pool, leading to the lowest DNAm age; this raises a...

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Identifiers

PMID: 40632935
DOI: 10.18632/aging.206276
PMCID: PMC12339025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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