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Article

ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis.

Scientific reports - 20 Aug 2018

Pepelyayeva Yuliya, Rastall David P W, Aldhamen Yasser A, O'Connell Patrick, Raehtz Sandra, Alyaqoub Fadel S, Blake Maja K, Raedy Ashley M, Angarita Ariana M, Abbas Abdulraouf M, Pereira-Hicks Cristiane N, Roosa Sarah G, McCabe Laura, Amalfitano Andrea

Abstract excerpt

Ankylosing spondylitis (AS) is a prototypical sero-negative autoimmune disease that affects millions worldwide. Single nucleotide polymorphisms in the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) gene have been linked to AS via GWAS studies, however, the exact mechanism as to how ERAP1 contributes to pathogenesis of AS is not understood. We undertook µCT imaging and histologic analysis to evaluate bone...

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Source

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Identifiers

PMID: 30127455
DOI: 10.1038/s41598-018-30159-5
PMCID: PMC6102283

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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