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Article

High glucose stimulating ECM remodeling and an inflammatory phenotype in the IPFP via upregulation of MFAP5 expression.

Biochemical and biophysical research communications - 23 Apr 2022

Dong Xiao-Ying, Yin Jing-Xia, Zhang Hao, Liao Yong

Abstract excerpt

Extracellular matrix (ECM) remodeling and inflammation in the infrapatellar fat pad (IPFP) are associated with cartilage degeneration and the severity of osteoarthritis (OA). Diabetes is associated with the progression of OA. However, it is still unclear whether diabetes can promote osteoarthritis by targeting the IPFP. In this study, we established a high-fat diet/streptozotocin (HFD/STZ)-induced diabetes mouse...

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Share to Adipose Tissue
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Extracellular Matrix

Share to Fibrosis

Share to Interleukin-6

Share to Osteoarthritis, Knee

Share to Receptor, Platelet-Derived Growth Factor alpha

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Identifiers

PMID: 35240498
DOI: 10.1016/j.bbrc.2022.02.077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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