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Article

Genetics and Age-Related Macular Degeneration: A Practical Review for Clinicians.

Frontiers in bioscience (Scholar edition) - 29 Feb 2024

Nguyen Julia, Brantley Milam A, Schwartz Stephen G

Abstract excerpt

Age-related macular degeneration (AMD) is a multifactorial genetic disease, with at least 52 identifiable associated gene variants at 34 loci, including variants in complement factor H (CFH) and age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase-1 (ARMS2/HTRA1). Genetic factors account for up to 70% of disease variability. However, population-based genetic risk scores are...

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Identifiers

PMID: 38538345
DOI: 10.31083/j.fbs1601003

Genes

ARMS2
CFH
HTRA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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